GPIHBP1

Across TCGA cell cohorts, GPIHBP1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GPIHBP1-associated genes across cancer lineages are PRAMEF10, PRAMEF17, and ACSM4. Each is linked with GPIHBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPIHBP1-to-partner and partner-to-GPIHBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF10 grouped by GPIHBP1-low versus GPIHBP1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPIHBP1→partner) and Y-score (partner→GPIHBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	ACSM4 →	+0.043	+4.044	.003	.009	3	1
LUNG_SCLC	PRAMEF25 →	+0.175	+4.523	<.001	.003	3	1
LUNG_SCLC	PRAMEF33 →	+0.490	+5.614	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PRAMEF10 by GPIHBP1 expression — LUNG_SCLC

Explore this box plot interactively →