GPIHBP1

Across TCGA pan-cancer cohorts, GPIHBP1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of GPIHBP1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where GPIHBP1 RNA is repressed in tumor relative to normal tissue. In most cancer types GPIHBP1 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KICH, and BLCA are the cancer types where GPIHBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPIHBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−4.173	<.001	11	view →
KICH	Male	All	−3.060	<.001	11	view →
BLCA	Male	All	−2.897	<.001	11	view →
KIRP	Male	II,III,IV	−2.771	<.001	11	view →
LUSC	Female	II,III,IV	−5.247	<.001	9	view →
UCEC	All	III,IV	−3.610	<.001	8	view →
HNSC	Male	IV	−1.518	<.001	8	view →
LIHC	All	II,III,IV	+1.087	<.001	8	view →
COAD	Female	II,III,IV	−0.915	<.001	8	view →
THCA	All	IV	−1.750	<.001	7	view →
BRCA	All	II,III,IV	−3.431	<.001	6	view →
KIRC	Male	II,III,IV	−1.000	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

GPIHBP1–LUAD

Open the LUAD breakdown →