GPI

Across TCGA pan-cancer cohorts, GPI mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GPI data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GPI mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GPI expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where GPI mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.700	0.964	<.001	52	view →
HNSC	DFS	Quartile	II,III,IV	0.865	0.988	.030	5	view →
LSCC	DFS	Tertile	All	0.849	0.552	.009	5	view →
UCEC	DFS	Median	II,III,IV	0.880	0.536	.044	4	view →
CCRCC	DFS	Tertile	III,IV	1.000	0.811	.024	3	view →
GBM	DFS	Median	All	0.830	0.667	.012	3	view →
PDAC	DFS	Median	III,IV	0.492	0.833	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GPI–LUAD (OS)

Open the LUAD breakdown →