GPI

Across TCGA pan-cancer cohorts, GPI RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of GPI’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where GPI RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPI is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LUAD, KIRP, and KIRC are the cancer types where GPI tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPI RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+1.451	<.001	11	view →
KIRP	Female	II,III,IV	+1.288	<.001	11	view →
KIRC	Female	All	+1.061	<.001	11	view →
COAD	Female	II,III,IV	+0.992	<.001	11	view →
HNSC	Male	II,III,IV	+0.915	<.001	11	view →
LUSC	Female	All	+1.907	<.001	9	view →
LIHC	Female	II,III,IV	+1.659	<.001	9	view →
UCEC	All	III,IV	+1.597	<.001	8	view →
STAD	All	II,III,IV	+0.842	<.001	8	view →
BRCA	All	III,IV	+0.647	<.001	6	view →
BLCA	All	All	+0.704	.001	5	view →
READ	All	III,IV	+1.000	.005	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

GPI–LUAD

Open the LUAD breakdown →