GPI

Across TCGA patient cohorts, GPI mutation is significantly associated with the RNA expression of many other genes, with 4,033 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPI-associated genes across cancer lineages are MTFP1, DENND1A, and CCL4. Each is linked with GPI in more than 2 cancer types. Because this analysis shows association rather than direction, both GPI-to-partner and partner-to-GPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTFP1 grouped by GPI-low versus GPI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPI→partner) and Y-score (partner→GPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTFP1 →	+0.503	+4.000	.002	<.001	3	3
UCEC	DENND1A →	+0.373	+3.480	.002	.002	3	3
UCEC	CCL4 →	+0.909	+3.095	<.001	<.001	3	2
UCEC	UHRF1 →	+1.013	+2.917	<.001	<.001	3	2
UCEC	TRAC →	+0.912	+2.700	.002	.005	3	2
LUAD	TSPY3 →	+1.005	+4.730	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,033 associations by consensus.

MTFP1 by GPI expression — UCEC

Explore this box plot interactively →