GPI

Across TCGA cell cohorts, GPI RNA expression is significantly associated with the go_rna of many other GO terms, with 3,953 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GPI-associated GO terms across cancer lineages are Canonical glycolysis, Glucose catabolic process to pyruvate, and Glycolytic process through fructose-6-phosphate. Each is linked with GPI in more than 12 cancer types. Because this analysis shows association rather than direction, both GPI-to-partner and partner-to-GPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Canonical glycolysis grouped by GPI-low versus GPI-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPI→partner) and Y-score (partner→GPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Canonical glycolysis →	+0.120	+0.893	<.001	<.001	3	13
BLOOD_Lymphoma	Glucose catabolic process to pyruvate →	+0.120	+0.893	<.001	<.001	3	13
BLOOD_Lymphoma	Glycolytic process through fructose-6-phosphate →	+0.122	+0.817	<.001	.002	3	12
BLOOD_Lymphoma	Glycolytic process through glucose-6-phosphate →	+0.122	+0.817	<.001	.002	3	12
SKIN	Nicotinamide nucleotide metabolic process →	+0.072	+1.050	<.001	<.001	3	12
OVARY	Mitochondrial potassium ion transmembrane transport →	+0.146	+0.728	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,953 associations by consensus.

Canonical glycolysis by GPI expression — BLOOD_Lymphoma

Explore this box plot interactively →