GPI

Across TCGA cell cohorts, GPI mutation is significantly associated with the RNA expression of many other genes, with 324 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPI-associated genes across cancer lineages are KSR2, TAS2R39, and NPPB. Each is linked with GPI in more than 1 cancer types. Because this analysis shows association rather than direction, both GPI-to-partner and partner-to-GPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KSR2 grouped by GPI-low versus GPI-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPI→partner) and Y-score (partner→GPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KSR2 →	+0.292	+3.540	.003	.005	3	2
BLOOD_Leukemia	TAS2R39 →	+0.040	+3.661	.002	.001	3	2
BLOOD_Leukemia	NPPB →	+0.117	+3.662	<.001	.003	3	1
BLOOD_Leukemia	SLC28A2 →	+0.046	+3.744	<.001	.003	3	1
BLOOD_Leukemia	TENM2 →	+0.431	+3.362	<.001	.007	3	1
BLOOD_Leukemia	CYP39A1 →	+0.192	+3.091	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 324 associations by consensus.

KSR2 by GPI expression — BLOOD_Leukemia

Explore this box plot interactively →