GPHN

Across TCGA patient cohorts, GPHN protein abundance is significantly associated with the RNA expression of many other genes, with 14,479 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GPHN-associated genes across cancer lineages are CCDC196, EXD2, and MPP5. Each is linked with GPHN in more than 7 cancer types. Because this analysis shows association rather than direction, both GPHN-to-partner and partner-to-GPHN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPHN versus CCDC196 in COAD, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPHN→partner) and Y-score (partner→GPHN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CCDC196 →	+0.782	+0.447	<.001	<.001	3	8
HNSC	EXD2 →	+0.645	+0.377	<.001	<.001	3	8
OV	MPP5 →	+0.508	+0.366	<.001	<.001	3	7
BRCA	VTI1B →	+0.422	+0.396	<.001	<.001	3	6
OV	ERG28 →	+0.704	+0.424	<.001	<.001	3	6
COAD	TIMM9 →	+0.377	+0.321	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,479 associations by consensus.

GPHN vs CCDC196 — COAD

Explore this scatter interactively →