GPHN

Across TCGA pan-cancer cohorts, GPHN RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GPHN data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher GPHN RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GPHN expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

BRCA, KIRC, and BLCA are the cancer types where GPHN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	All	0.973	0.925	<.001	87	view →
KIRC	OS	Median	All	0.718	0.554	<.001	87	view →
BLCA	OS	Median	All	0.333	0.530	<.001	63	view →
CHOL	DFS	Tertile	II,III,IV	0.085	0.571	.002	45	view →
LAML	DFS	Quartile	All	0.710	0.288	<.001	40	view →
UVM	DFS	Median	III,IV	0.220	0.664	.020	34	view →
LGG	DFS	Median	All	0.476	0.312	<.001	32	view →
ACC	DFS	Quartile	All	0.125	0.785	.006	29	view →
KIRP	DFS	Median	All	0.886	0.580	.007	22	view →
HNSC	OS	Quartile	II,III,IV	0.616	0.753	.023	22	view →
GBM	OS	Median	All	0.467	0.224	.004	21	view →
READ	DFS	Tertile	IV	0.798	0.328	.013	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GPHN–BRCA (DFS)

Open the BRCA breakdown →