GPHN

Across TCGA patient cohorts, GPHN mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPHN-associated genes across cancer lineages are eIF4E, C-Raf, and MSH6. Each is linked with GPHN in more than 3 cancer types. Because this analysis shows association rather than direction, both GPHN-to-partner and partner-to-GPHN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GPHN-low versus GPHN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPHN→partner) and Y-score (partner→GPHN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.192	+2.169	.004	.003	3	4
COAD	C-Raf →	+0.195	+2.815	.015	.036	3	2
UCEC	MSH6 →	-0.361	-1.700	<.001	.040	3	2
UCEC	p62 Lck ligand →	+0.383	+2.000	<.001	<.001	3	2
UCEC	PKC-delta_pS664 →	-0.090	-1.999	.020	.008	3	2
UCEC	EGFR_pY1068 →	-0.217	-1.459	.007	.012	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eIF4E by GPHN expression — UCEC

Explore this box plot interactively →