GPHN

Across TCGA cell cohorts, GPHN mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GPHN-associated genes across cancer lineages are OR10AG1, PRORY, and DAZ3. Each is linked with GPHN in more than 1 cancer types. Because this analysis shows association rather than direction, both GPHN-to-partner and partner-to-GPHN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10AG1 grouped by GPHN-low versus GPHN-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPHN→partner) and Y-score (partner→GPHN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10AG1 →	+0.032	+4.662	<.001	.005	3	2
BLOOD_Myeloma	PRORY →	+1.180	+4.807	<.001	.006	3	1
BLOOD_Myeloma	DAZ3 →	+1.563	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SALL3 →	+0.060	+4.807	<.001	.006	3	1
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
LUNG_NSCLC_LUAD	BHLHE23 →	+0.060	+4.947	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR10AG1 by GPHN expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →