Across TCGA cell cohorts, GPC6 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPC6-associated genes across cancer lineages are VN1R4, LAIR2, and AMY1B. Each is linked with GPC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPC6-to-partner and partner-to-GPC6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC6→partner) and Y-score (partner→GPC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1
SKIN	LAIR2 →	+0.105	+2.832	<.001	.002	3	1
SKIN	AMY1B →	+0.018	+3.023	<.001	.002	3	1
SKIN	SCRT2 →	+0.004	+2.832	<.001	.002	3	1
LUNG_NSCLC_LUAD	PRAMEF14 →	+0.007	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	CXorf51B →	+1.577	+4.813	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

GPC6 survival (RNA) · tumor vs normal (RNA) · all GPC6 data types