GPC5-IT1

Across TCGA pan-cancer cohorts, GPC5-IT1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated GPC5-IT1 data layer.

The strongest signal is observed in thymoma (THYM), where higher GPC5-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPC5-IT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LAML show a favorable association.

THYM, HNSC, and GBM are the cancer types where GPC5-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Tertile	All	0.186	0.880	<.001	72	view →
HNSC	OS	Tertile	II,III,IV	0.799	0.335	.008	54	view →
GBM	DFS	Median	All	0.174	0.314	<.001	42	view →
LGG	DFS	Tertile	All	0.742	0.868	<.001	41	view →
UCEC	DFS	Tertile	All	0.750	0.902	.005	36	view →
BLCA	DFS	Tertile	All	0.346	0.636	.001	21	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
CHOL	OS	Tertile	All	0.089	0.673	.018	18	view →
READ	OS	Tertile	IV	0.386	0.741	.037	18	view →
LAML	DFS	Tertile	All	0.615	0.340	.038	12	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	9	view →
SARC	OS	Tertile	All	1.000	0.802	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

GPC5-IT1–THYM (OS)

Open the THYM breakdown →