GPC5-AS2

Across TCGA pan-cancer cohorts, GPC5-AS2 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated GPC5-AS2 data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher GPC5-AS2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GPC5-AS2 expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

ESCA, KIRC, and KIRP are the cancer types where GPC5-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	III,IV	1.000	0.347	.003	54	view →
KIRC	DFS	Tertile	IV	0.280	0.616	.015	42	view →
KIRP	OS	Tertile	All	0.688	0.935	.006	42	view →
SKCM	OS	Tertile	All	0.102	0.343	.007	30	view →
COAD	DFS	Tertile	IV	0.028	0.496	<.001	27	view →
THCA	DFS	Tertile	IV	0.144	0.884	<.001	27	view →
LGG	DFS	Tertile	All	0.567	0.778	.011	9	view →
STAD	OS	Tertile	IV	0.156	0.506	.021	9	view →
ACC	OS	Tertile	II,III,IV	0.508	0.778	.034	9	view →
UCEC	DFS	Tertile	All	0.825	0.898	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

GPC5-AS2–ESCA (OS)

Open the ESCA breakdown →