GPC4

Across TCGA pan-cancer cohorts, GPC4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GPC4 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GPC4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPC4 expression acts as an unfavorable survival marker.

HNSC, CCRCC, and PDAC are the cancer types where GPC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.328	0.889	.014	24	view →
CCRCC	OS	Tertile	IV	0.077	1.000	.024	23	view →
PDAC	DFS	Tertile	All	0.702	0.951	.002	19	view →
LSCC	DFS	Quartile	All	0.917	1.000	.013	9	view →
GBM	OS	Tertile	All	0.777	0.926	.018	5	view →
LUAD	DFS	Tertile	All	0.714	1.000	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GPC4–HNSC (DFS)

Open the HNSC breakdown →