GPC4

Across TCGA patient cohorts, GPC4 mutation is significantly associated with the RNA expression of many other genes, with 4,916 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPC4-associated genes across cancer lineages are PSMA1, RNA5SP408, and ATP5MC1. Each is linked with GPC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPC4-to-partner and partner-to-GPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMA1 grouped by GPC4-low versus GPC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC4→partner) and Y-score (partner→GPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMA1 →	+0.510	+2.254	<.001	<.001	3	3
UCEC	RNA5SP408 →	+0.208	+2.239	.002	<.001	3	3
UCEC	ATP5MC1 →	+0.492	+1.947	<.001	<.001	3	3
UCEC	SNRPD1 →	+0.593	+2.917	<.001	<.001	3	3
UCEC	TMEM126A →	+0.521	+2.536	<.001	<.001	3	3
LUAD	TPM4P1 →	+0.104	+2.925	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,916 associations by consensus.

PSMA1 by GPC4 expression — UCEC

Explore this box plot interactively →