GPC4

Across TCGA cell cohorts, GPC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,159 significant associations in total. CNS shows the largest number of these associations.

The most reproducible GPC4-associated GO terms across cancer lineages are Nuclear migration, Potassium ion transmembrane transport, and Oxidative phosphorylation. Each is linked with GPC4 in more than 8 cancer types. Because this analysis shows association rather than direction, both GPC4-to-partner and partner-to-GPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear migration grouped by GPC4-low versus GPC4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC4→partner) and Y-score (partner→GPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Nuclear migration →	+0.064	+2.466	.003	<.001	3	9
BLOOD_Myeloma	Potassium ion transmembrane transport →	-0.051	-1.878	<.001	.001	3	8
SOFT_TISSUE	Oxidative phosphorylation →	+0.050	+1.750	.001	<.001	3	8
SOFT_TISSUE	Proton transmembrane transport →	+0.071	+2.580	<.001	<.001	3	7
BLOOD_Leukemia	Regulation of syncytium formation by plasma membrane fusion →	+0.065	+1.579	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Membrane depolarization during action potential →	-0.355	-2.147	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,159 associations by consensus.

Nuclear migration by GPC4 expression — OVARY

Explore this box plot interactively →