GPC3

Across TCGA cell cohorts, GPC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,562 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GPC3-associated GO terms across cancer lineages are Glial cell fate commitment, Cytoplasmic translation, and Regulation of membrane repolarization. Each is linked with GPC3 in more than 10 cancer types. Because this analysis shows association rather than direction, both GPC3-to-partner and partner-to-GPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glial cell fate commitment grouped by GPC3-low versus GPC3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC3→partner) and Y-score (partner→GPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Glial cell fate commitment →	+1.776	+1.974	<.001	.002	3	11
LUNG_SCLC	Cytoplasmic translation →	+0.093	+2.796	<.001	.002	3	9
LIVER	Regulation of membrane repolarization →	-0.204	-4.598	<.001	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Calcium ion transport →	-0.062	-1.551	<.001	<.001	3	8
SOFT_TISSUE	Negative regulation of mRNA catabolic process →	+0.071	+3.338	<.001	<.001	3	8
LIVER	Positive regulation of natural killer cell activation →	-0.378	-7.162	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,562 associations by consensus.

Glial cell fate commitment by GPC3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →