Across TCGA cell cohorts, GPC2 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPC2-associated genes across cancer lineages are PRND, FAM9A, and SPO11. Each is linked with GPC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPC2-to-partner and partner-to-GPC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC2→partner) and Y-score (partner→GPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRND →	+0.011	+4.874	<.001	.002	3	1
BLOOD_Leukemia	FAM9A →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	SPO11 →	+0.019	+4.969	<.001	.003	3	1
OVARY	TGIF2LX →	+0.488	+3.095	<.001	.009	3	1
OVARY	GPR148 →	+0.044	+3.095	<.001	.009	3	1
OVARY	MRGPRX2 →	+0.012	+3.405	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

GPC2 survival (RNA) · tumor vs normal (RNA) · all GPC2 data types