GPC1

Across TCGA patient cohorts, GPC1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,959 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GPC1-associated genes across cancer lineages are MEIS3, PALLD, and FRMD6. Each is linked with GPC1 in more than 7 cancer types. Because this analysis shows association rather than direction, both GPC1-to-partner and partner-to-GPC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPC1 versus MEIS3 in BRCA, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC1→partner) and Y-score (partner→GPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MEIS3 →	+1.078	+0.438	<.001	<.001	3	7
COAD	PALLD →	+0.858	+0.436	<.001	<.001	2	8
LSCC	FRMD6 →	+1.190	+0.903	<.001	<.001	3	7
COAD	SPOCK1 →	+1.526	+0.520	<.001	<.001	3	7
BRCA	EDIL3 →	+1.248	+0.470	<.001	<.001	3	7
COAD	CERCAM →	+0.995	+0.471	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,959 associations by consensus.

GPC1 vs MEIS3 — BRCA

Explore this scatter interactively →