GPC1

Across TCGA patient cohorts, GPC1 mutation is significantly associated with the RNA expression of many other genes, with 4,579 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPC1-associated genes across cancer lineages are LINC00294, MMP12, and LINC00909. Each is linked with GPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPC1-to-partner and partner-to-GPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00294 grouped by GPC1-low versus GPC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC1→partner) and Y-score (partner→GPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC00294 →	+0.331	+1.776	.005	<.001	3	2
UCEC	MMP12 →	+1.204	+3.191	<.001	<.001	3	2
UCEC	LINC00909 →	+0.330	+1.551	.003	.002	3	2
SKCM	MIR5192 →	+0.688	+3.501	<.001	.005	3	2
LIHC	NME2P2 →	+0.275	+5.108	<.001	.008	3	2
LIHC	NEUROG2-AS1 →	+0.103	+5.186	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,579 associations by consensus.

LINC00294 by GPC1 expression — UCEC

Explore this box plot interactively →