GPBP1L1

Across TCGA patient cohorts, GPBP1L1 mutation is significantly associated with the RNA expression of many other genes, with 2,793 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPBP1L1-associated genes across cancer lineages are RN7SKP171, RNU6-855P, and RNU11-2P. Each is linked with GPBP1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPBP1L1-to-partner and partner-to-GPBP1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP171 grouped by GPBP1L1-low versus GPBP1L1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPBP1L1→partner) and Y-score (partner→GPBP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP171 →	+0.161	+7.142	.005	<.001	3	2
COAD	RNU6-855P →	+1.082	+5.693	<.001	.003	3	2
COAD	RNU11-2P →	+1.138	+5.212	<.001	.007	3	2
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
UCEC	GOLGA6L11P →	+0.011	+3.140	<.001	.004	3	2
UCEC	RNU6-362P →	+0.060	+3.668	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,793 associations by consensus.

RN7SKP171 by GPBP1L1 expression — COAD

Explore this box plot interactively →