GPBP1

Across TCGA pan-cancer cohorts, GPBP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GPBP1 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GPBP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GPBP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where GPBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.937	0.714	<.001	47	view →
LUAD	OS	Quartile	All	0.908	0.625	.010	21	view →
PDAC	DFS	Median	II,III,IV	0.841	0.724	.031	7	view →
GBM	OS	Median	All	0.444	0.297	.031	2	view →
UCEC	DFS	Median	All	1.000	0.939	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GPBP1–HNSC (OS)

Open the HNSC breakdown →