GPBP1

Across TCGA pan-cancer cohorts, GPBP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GPBP1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GPBP1 RNA is repressed in tumor relative to normal tissue. In most cancer types GPBP1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KIRC are the cancer types where GPBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.473	<.001	10	view →
LIHC	Female	II,III,IV	+1.169	<.001	9	view →
KIRC	All	All	+0.292	<.001	7	view →
HNSC	All	III,IV	+0.303	.012	5	view →
KICH	All	All	−0.765	<.001	4	view →
CHOL	Female	All	+2.013	<.001	3	view →
BRCA	All	II,III,IV	+0.178	.012	3	view →
KIRP	All	IV	+0.659	.047	2	view →
UCEC	All	All	−0.520	.003	2	view →
STAD	All	II,III,IV	+0.373	.018	2	view →
ESCA	All	All	+0.342	.012	2	view →
COAD	Male	All	+0.291	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GPBP1–THCA

Open the THCA breakdown →