GPBP1

Across TCGA patient cohorts, GPBP1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPBP1-associated genes across cancer lineages are MEK1, Shc_pY317, and EGFR_pY1068. Each is linked with GPBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPBP1-to-partner and partner-to-GPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GPBP1-low versus GPBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPBP1→partner) and Y-score (partner→GPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.332	+2.222	.013	.010	3	2
UCEC	Shc_pY317 →	-0.144	-1.700	.009	.042	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.247	.006	.001	3	1
UCEC	eIF4G →	+0.298	+1.847	.008	.008	3	1
UCEC	A-Raf_pS299 →	-0.123	-2.115	.004	.017	3	1
UCEC	INPP4B →	-0.380	-3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MEK1 by GPBP1 expression — UCEC

Explore this box plot interactively →