GPBAR1

Across TCGA patient cohorts, GPBAR1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPBAR1-associated genes across cancer lineages are EGFR_pY1173, Myosin-IIa_pS1943, and c-Met_pY1235. Each is linked with GPBAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPBAR1-to-partner and partner-to-GPBAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by GPBAR1-low versus GPBAR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPBAR1→partner) and Y-score (partner→GPBAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.106	+2.833	.030	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.294	+2.820	.020	.036	3	1
UCEC	c-Met_pY1235 →	+0.114	+2.817	.012	.036	3	1
UCEC	HER3_pY1289 →	+0.135	+2.833	.010	.035	2	1
UCEC	VEGFR2 →	+0.361	+2.820	.047	.036	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EGFR_pY1173 by GPBAR1 expression — UCEC

Explore this box plot interactively →