GPBAR1

Across TCGA pan-cancer cohorts, GPBAR1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GPBAR1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where GPBAR1 RNA is repressed in tumor relative to normal tissue. In most cancer types GPBAR1 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and LUAD are the cancer types where GPBAR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPBAR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−2.382	<.001	11	view →
KICH	Male	All	−2.730	<.001	9	view →
LUAD	Female	II,III,IV	−1.347	<.001	9	view →
LUSC	Female	All	−1.833	<.001	8	view →
BRCA	All	II,III,IV	−1.626	<.001	8	view →
KIRP	Male	All	−1.423	<.001	6	view →
KIRC	Male	II,III,IV	−1.105	<.001	6	view →
UCEC	All	III,IV	−0.997	<.001	6	view →
THCA	Male	II,III,IV	−0.344	.008	5	view →
CHOL	All	All	+0.870	.010	1	view →
STAD	All	IV	−0.646	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GPBAR1–BLCA

Open the BLCA breakdown →