GPBAR1

Across TCGA cell cohorts, GPBAR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,813 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GPBAR1-associated GO terms across cancer lineages are Adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway, Negative regulation of mRNA splicing, via spliceosome, and Negative regulation of mRNA processing. Each is linked with GPBAR1 in more than 8 cancer types. Because this analysis shows association rather than direction, both GPBAR1-to-partner and partner-to-GPBAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway grouped by GPBAR1-low versus GPBAR1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPBAR1→partner) and Y-score (partner→GPBAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway →	-0.149	-0.861	.006	.005	3	9
LARGE_INTESTINE	Negative regulation of mRNA splicing, via spliceosome →	+0.101	+0.193	<.001	.004	3	8
LARGE_INTESTINE	Negative regulation of mRNA processing →	+0.097	+0.192	<.001	.004	3	8
SOFT_TISSUE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.117	+0.528	<.001	.001	2	9
BONE	Oocyte growth →	+0.216	+0.184	<.001	.002	3	7
LARGE_INTESTINE	Positive regulation of growth rate →	-0.199	-0.181	.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,813 associations by consensus.

Adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway by GPBAR1 expression — LUNG_SCLC

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