GPATCH2L

Across TCGA pan-cancer cohorts, GPATCH2L Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GPATCH2L data layer compared with 29 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GPATCH2L Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GPATCH2L expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, UCEC, and LUSC are the cancer types where GPATCH2L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.153	0.835	<.001	30	view →
UCEC	DFS	Median	All	1.000	0.824	.003	18	view →
LUSC	OS	Median	All	0.081	0.818	<.001	18	view →
SKCM	DFS	Median	III,IV	0.029	0.613	<.001	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LGG	OS	Median	All	0.324	0.799	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GPATCH2L–LUAD (OS)

Open the LUAD breakdown →