GPATCH11

Across TCGA patient cohorts, GPATCH11 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPATCH11-associated genes across cancer lineages are FOXO3a, PDK1_pS241, and TIGAR. Each is linked with GPATCH11 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPATCH11-to-partner and partner-to-GPATCH11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by GPATCH11-low versus GPATCH11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPATCH11→partner) and Y-score (partner→GPATCH11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	-0.111	-3.292	.015	.010	3	2
UCEC	PDK1_pS241 →	+0.196	+2.459	.010	.019	3	1
UCEC	TIGAR →	+0.189	+2.727	.006	.003	3	1
UCEC	Caspase-7-cleavedD198 →	+0.839	+2.479	.001	.010	3	1
UCEC	Caspase-8 →	-0.263	-2.700	.020	.006	3	1
UCEC	Chk2_pT68 →	-0.175	-2.700	.037	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOXO3a by GPATCH11 expression — UCEC

Explore this box plot interactively →