GPATCH11

Across TCGA pan-cancer cohorts, GPATCH11 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GPATCH11’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPATCH11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPATCH11 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where GPATCH11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPATCH11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.759	<.001	12	view →
LIHC	Male	All	+0.722	<.001	9	view →
THCA	Male	III,IV	−0.661	<.001	9	view →
KIRC	Male	All	+0.454	<.001	9	view →
BLCA	All	All	+0.589	.001	6	view →
BRCA	All	All	−0.561	<.001	6	view →
KICH	Female	All	−1.205	<.001	5	view →
LUAD	Female	II,III,IV	−0.524	<.001	5	view →
CHOL	All	All	+1.057	<.001	4	view →
STAD	All	All	+0.357	.010	4	view →
ESCA	All	All	+0.496	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GPATCH11–HNSC

Open the HNSC breakdown →