GPATCH1

Across TCGA cell cohorts, GPATCH1 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPATCH1-associated genes across cancer lineages are FBXW10, SERPINA12, and OPRPN. Each is linked with GPATCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPATCH1-to-partner and partner-to-GPATCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by GPATCH1-low versus GPATCH1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPATCH1→partner) and Y-score (partner→GPATCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.267	+3.714	<.001	.001	3	2
PANCREAS	SERPINA12 →	+0.016	+5.614	<.001	.002	3	1
PANCREAS	OPRPN →	+0.029	+5.000	<.001	.006	3	1
PANCREAS	OR1L6 →	+0.019	+5.000	<.001	.006	3	1
PANCREAS	DUSP21 →	+0.061	+5.000	<.001	.006	3	1
PANCREAS	USP17L3 →	+0.016	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

FBXW10 by GPATCH1 expression — LARGE_INTESTINE

Explore this box plot interactively →