GPAT4

Across TCGA patient cohorts, GPAT4 mutation is significantly associated with the RNA expression of many other genes, with 3,971 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPAT4-associated genes across cancer lineages are LINC01815, SLC25A4, and BAG3. Each is linked with GPAT4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPAT4-to-partner and partner-to-GPAT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01815 grouped by GPAT4-low versus GPAT4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPAT4→partner) and Y-score (partner→GPAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC01815 →	+0.890	+5.103	<.001	.008	3	3
UCEC	SLC25A4 →	+0.561	+2.654	<.001	<.001	3	2
UCEC	BAG3 →	+0.650	+2.643	<.001	<.001	3	2
UCEC	PRXL2C →	+0.385	+1.789	.004	.007	3	2
UCEC	ABHD3 →	+0.737	+2.273	<.001	<.001	3	2
UCEC	SNRNP25 →	+0.329	+2.013	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,971 associations by consensus.

LINC01815 by GPAT4 expression — CESC

Explore this box plot interactively →