GPAT4

Across TCGA pan-cancer cohorts, GPAT4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GPAT4 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher GPAT4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPAT4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

MESO, HNSC, and BLCA are the cancer types where GPAT4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.384	0.695	<.001	132	view →
HNSC	DFS	Median	III,IV	0.740	0.616	.002	76	view →
BLCA	DFS	Tertile	All	0.671	0.491	.002	47	view →
ACC	DFS	Tertile	All	0.334	0.780	.001	29	view →
UVM	OS	Tertile	All	0.385	0.848	.011	29	view →
OV	OS	Median	III,IV	0.261	0.375	.003	24	view →
SARC	OS	Median	All	0.776	0.898	.001	20	view →
KICH	DFS	Quartile	III,IV	0.324	0.913	.013	17	view →
LIHC	OS	Tertile	All	0.686	0.874	.002	17	view →
SCLC	OS	Quartile	All	0.632	0.297	.002	13	view →
UCS	OS	Tertile	IV	1.000	0.389	.049	12	view →
READ	OS	Median	III,IV	0.647	0.327	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GPAT4–MESO (OS)

Open the MESO breakdown →