GPAM

Across TCGA patient cohorts, GPAM mutation is significantly associated with the RNA expression of many other genes, with 3,444 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPAM-associated genes across cancer lineages are RPL32P8, TRIM26, and RNU6-709P. Each is linked with GPAM in more than 2 cancer types. Because this analysis shows association rather than direction, both GPAM-to-partner and partner-to-GPAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL32P8 grouped by GPAM-low versus GPAM-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPAM→partner) and Y-score (partner→GPAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL32P8 →	+0.171	+3.748	<.001	.008	3	3
UCEC	TRIM26 →	+0.295	+1.805	.001	<.001	3	3
CESC	RNU6-709P →	+0.192	+5.852	<.001	<.001	3	3
UCEC	PSMD7 →	+0.386	+1.962	.001	<.001	3	3
UCEC	RNA5SP412 →	+0.439	+1.568	<.001	.002	3	2
HNSC	LINC02546 →	+0.049	+4.709	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,444 associations by consensus.

RPL32P8 by GPAM expression — HNSC

Explore this box plot interactively →