GPAM

Across TCGA pan-cancer cohorts, GPAM RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GPAM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GPAM RNA is repressed in tumor relative to normal tissue. In most cancer types GPAM is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, BRCA, and THCA are the cancer types where GPAM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPAM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.594	<.001	12	view →
BRCA	All	III,IV	−3.236	<.001	8	view →
THCA	Male	III,IV	−1.837	<.001	8	view →
HNSC	Female	III,IV	+0.720	.010	5	view →
CHOL	All	All	−3.113	<.001	3	view →
BLCA	Female	All	+0.736	.032	2	view →
KIRP	Female	II,III,IV	+0.544	.037	2	view →
LIHC	All	III,IV	+0.815	.047	1	view →
KIRP	Male	All	−0.387	.008	1	view →
LUAD	All	All	+0.242	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

GPAM–KIRC

Open the KIRC breakdown →