GPAM

Across TCGA patient cohorts, GPAM mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPAM-associated genes across cancer lineages are Ku80, Caspase-7-cleavedD198, and C-Raf. Each is linked with GPAM in more than 1 cancer types. Because this analysis shows association rather than direction, both GPAM-to-partner and partner-to-GPAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GPAM-low versus GPAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPAM→partner) and Y-score (partner→GPAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.201	+1.672	.005	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.403	+2.019	.026	.005	3	2
UCEC	C-Raf →	+0.104	+1.662	.018	.010	3	2
LUSC	NF-kB-p65_pS536 →	+0.430	+2.816	.043	.036	3	1
LUSC	Dvl3 →	+0.321	+2.816	.002	.036	3	1
UCEC	14-3-3_beta →	-0.102	-2.558	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Ku80 by GPAM expression — UCEC

Explore this box plot interactively →