GPAM

Across TCGA cell cohorts, GPAM mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPAM-associated genes across cancer lineages are LRRC18, OR2T7, and GNG8. Each is linked with GPAM in more than 1 cancer types. Because this analysis shows association rather than direction, both GPAM-to-partner and partner-to-GPAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC18 grouped by GPAM-low versus GPAM-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPAM→partner) and Y-score (partner→GPAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LRRC18 →	+0.162	+4.523	<.001	.003	3	1
LUNG_SCLC	OR2T7 →	+0.005	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUAD	GNG8 →	+0.244	+4.887	.003	.009	3	1
LUNG_NSCLC_LUAD	CNGA2 →	+0.036	+4.887	<.001	.009	3	1
LARGE_INTESTINE	APOC3 →	+2.314	+4.115	<.001	.001	3	1
LARGE_INTESTINE	PRAMEF33 →	+0.076	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

LRRC18 by GPAM expression — LUNG_SCLC

Explore this box plot interactively →