GPALPP1

Across TCGA pan-cancer cohorts, GPALPP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GPALPP1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GPALPP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GPALPP1 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

HNSC, COAD, and CCRCC are the cancer types where GPALPP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.777	0.905	.003	45	view →
COAD	DFS	Median	All	1.000	0.926	.022	24	view →
CCRCC	DFS	Tertile	II,III,IV	0.814	0.435	.010	19	view →
LUAD	DFS	Tertile	All	1.000	0.661	.007	11	view →
PDAC	OS	Tertile	II,III,IV	0.250	0.573	.033	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GPALPP1–HNSC (OS)

Open the HNSC breakdown →