GPALPP1

Across TCGA pan-cancer cohorts, GPALPP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GPALPP1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GPALPP1 RNA is repressed in tumor relative to normal tissue. In most cancer types GPALPP1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, COAD, and LIHC are the cancer types where GPALPP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPALPP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.377	<.001	9	view →
COAD	Male	All	+0.895	<.001	8	view →
LIHC	Male	All	+0.597	<.001	8	view →
KICH	Female	II,III,IV	−1.427	<.001	7	view →
HNSC	All	III,IV	+0.409	.002	7	view →
CHOL	All	All	+1.028	<.001	5	view →
LUSC	All	III,IV	−0.719	.004	5	view →
READ	All	All	+0.717	.009	4	view →
UCEC	All	All	−0.546	.003	2	view →
PAAD	Male	All	+0.520	.031	2	view →
PRAD	All	All	−0.221	.031	2	view →
BRCA	Female	All	−0.163	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GPALPP1–THCA

Open the THCA breakdown →