GPALPP1

Across TCGA patient cohorts, GPALPP1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPALPP1-associated genes across cancer lineages are FoxM1, Ku80, and STAT3_pY705. Each is linked with GPALPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPALPP1-to-partner and partner-to-GPALPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by GPALPP1-low versus GPALPP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPALPP1→partner) and Y-score (partner→GPALPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.336	+3.321	.013	.010	3	1
UCEC	Ku80 →	+0.325	+2.183	.008	.035	3	1
UCEC	STAT3_pY705 →	-0.348	-3.321	.011	.010	3	1
UCEC	PCNA →	+0.337	+3.321	.002	.010	2	1
UCEC	EGFR_pY1068 →	-0.290	-3.321	.027	.010	1	1
UCEC	C-Raf →	+0.202	+3.321	.007	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FoxM1 by GPALPP1 expression — UCEC

Explore this box plot interactively →