GP6

Across TCGA cell cohorts, GP6 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible GP6-associated genes across cancer lineages are SLC32A1, TNP2, and RTL4. Each is linked with GP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GP6-to-partner and partner-to-GP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by GP6-low versus GP6-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GP6→partner) and Y-score (partner→GP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC32A1 →	+0.991	+4.017	<.001	.007	3	1
OESOPHAGUS	TNP2 →	+0.029	+4.392	<.001	.003	3	1
SKIN	RTL4 →	+0.006	+5.415	<.001	.004	3	1
LARGE_INTESTINE	CCDC195 →	+0.065	+4.467	<.001	.004	3	1
OESOPHAGUS	ZNF730 →	+0.318	+4.108	<.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SLC32A1 by GP6 expression — OESOPHAGUS

Explore this box plot interactively →