GP6

Across TCGA pan-cancer cohorts, GP6 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GP6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GP6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GP6 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KICH, KIRC, and LUAD are the cancer types where GP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	+1.345	<.001	8	view →
KIRC	Male	III,IV	+0.595	<.001	8	view →
LUAD	All	All	−0.307	<.001	8	view →
LUSC	Female	All	−0.490	<.001	5	view →
THCA	All	All	−0.208	<.001	5	view →
LIHC	Male	All	−0.111	<.001	4	view →
UCEC	All	III,IV	−0.331	.043	2	view →
COAD	All	IV	+0.241	.025	1	view →
HNSC	All	IV	−0.232	.048	1	view →
STAD	Male	IV	+0.180	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GP6–KICH

Open the KICH breakdown →