GP5

Across TCGA cell cohorts, GP5 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GP5-associated genes across cancer lineages are PPP3R2, RASGEF1C, and DAZ1. Each is linked with GP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GP5-to-partner and partner-to-GP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP3R2 grouped by GP5-low versus GP5-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GP5→partner) and Y-score (partner→GP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PPP3R2 →	+0.023	+4.196	.002	.002	3	1
LARGE_INTESTINE	RASGEF1C →	+0.291	+3.404	<.001	.006	3	1
LARGE_INTESTINE	DAZ1 →	+0.605	+3.520	.001	.005	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
BREAST	GAGE12F →	+0.536	+5.169	<.001	.005	3	1
SKIN	GALP →	+0.017	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PPP3R2 by GP5 expression — BLOOD_Lymphoma

Explore this box plot interactively →