GP5

Across TCGA pan-cancer cohorts, GP5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GP5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GP5 RNA is repressed in tumor relative to normal tissue. In most cancer types GP5 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and UCEC are the cancer types where GP5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GP5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.717	<.001	10	view →
KICH	Female	All	−0.228	<.001	7	view →
UCEC	All	All	−0.485	<.001	6	view →
LUSC	Male	II,III,IV	−0.350	<.001	6	view →
KIRC	All	All	+0.192	<.001	6	view →
KIRP	All	All	−0.145	<.001	6	view →
BRCA	Female	II,III,IV	+0.090	<.001	6	view →
LIHC	All	II,III,IV	−0.109	.002	5	view →
STAD	Male	All	+0.123	.008	4	view →
BLCA	All	IV	−0.064	.008	3	view →
CHOL	All	All	−0.081	.024	2	view →
PRAD	All	All	−0.072	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GP5–THCA

Open the THCA breakdown →