GP2

Across TCGA patient cohorts, GP2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GP2-associated genes across cancer lineages are Caspase-7-cleavedD198, Ku80, and ACVRL1. Each is linked with GP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GP2-to-partner and partner-to-GP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GP2-low versus GP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GP2→partner) and Y-score (partner→GP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.117	+2.178	.002	.035	3	3
UCEC	Ku80 →	+0.264	+2.100	.003	.003	3	3
LUAD	ACVRL1 →	-0.128	-2.000	.035	.031	3	2
SKCM	Smad4 →	+0.136	+3.204	.005	.008	3	2
SKCM	Src_pY527 →	-0.520	-3.169	.004	.017	3	2
UCEC	Caspase-8 →	-0.259	-2.807	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by GP2 expression — COAD

Explore this box plot interactively →