GOT2

Across TCGA patient cohorts, GOT2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOT2-associated genes across cancer lineages are PRDX1, STAT5a, and TFRC. Each is linked with GOT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOT2-to-partner and partner-to-GOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by GOT2-low versus GOT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOT2→partner) and Y-score (partner→GOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.200	+3.000	.045	.036	3	1
UCEC	STAT5a →	+0.475	+3.000	.013	.036	3	1
UCEC	TFRC →	+0.601	+3.000	.019	.036	3	1
UCEC	Bcl-2 →	-0.344	-2.980	.040	.036	3	1
UCEC	Caspase-8 →	-0.291	-3.584	.016	.002	3	1
UCEC	Cyclin-B1 →	+0.604	+2.459	.026	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PRDX1 by GOT2 expression — UCEC

Explore this box plot interactively →