GOT2

Across TCGA cell cohorts, GOT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,731 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GOT2-associated GO terms across cancer lineages are DNA replication initiation, Mitotic DNA replication, and Double-strand break repair via break-induced replication. Each is linked with GOT2 in more than 15 cancer types. Because this analysis shows association rather than direction, both GOT2-to-partner and partner-to-GOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by GOT2-low versus GOT2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GOT2→partner) and Y-score (partner→GOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA replication initiation →	+0.187	+1.222	<.001	.001	3	16
LUNG_NSCLC_LUSC	Mitotic DNA replication →	+0.183	+0.934	.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.266	+1.101	<.001	<.001	3	14
LUNG_SCLC	Mitochondrial large ribosomal subunit assembly →	+0.142	+0.836	<.001	<.001	2	14
BLOOD_Lymphoma	Mitochondrial ribosome assembly →	+0.097	+1.129	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of centromeric sister chromatid cohesion →	+0.133	+0.924	.002	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,731 associations by consensus.

DNA replication initiation by GOT2 expression — BLOOD_Myeloma

Explore this box plot interactively →