GOT1L1

Across TCGA patient cohorts, GOT1L1 mutation is significantly associated with the RNA expression of many other genes, with 1,155 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOT1L1-associated genes across cancer lineages are RN7SL254P, POLR2DP2, and SLC25A1. Each is linked with GOT1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOT1L1-to-partner and partner-to-GOT1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL254P grouped by GOT1L1-low versus GOT1L1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOT1L1→partner) and Y-score (partner→GOT1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL254P →	+0.752	+5.392	<.001	.002	3	2
SKCM	POLR2DP2 →	+0.135	+2.705	<.001	.008	3	2
UCEC	SLC25A1 →	+0.539	+3.354	<.001	<.001	3	2
UCEC	CINP →	+0.290	+3.491	.002	.002	3	2
UCEC	NAGPA →	+0.380	+3.024	.001	<.001	3	2
UCEC	ENO2 →	+0.705	+2.415	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,155 associations by consensus.

RN7SL254P by GOT1L1 expression — COAD

Explore this box plot interactively →