GOT1L1

Across TCGA patient cohorts, GOT1L1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOT1L1-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and GATA6. Each is linked with GOT1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOT1L1-to-partner and partner-to-GOT1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GOT1L1-low versus GOT1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOT1L1→partner) and Y-score (partner→GOT1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.508	+3.019	.038	.019	3	2
UCEC	ERK2 →	+0.191	+2.321	.016	.006	3	1
UCEC	GATA6 →	-0.204	-2.321	.002	.034	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.414	+1.884	.019	.030	3	1
UCEC	Heregulin →	-0.151	-2.584	.002	.010	3	1
UCEC	MEK1 →	+0.348	+3.321	.021	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Caspase-7-cleavedD198 by GOT1L1 expression — UCEC

Explore this box plot interactively →